Studies on Nucleic Acid and Nucleic Acid Analogs. Part II
نویسندگان
چکیده
منابع مشابه
Studies on Nucleic Acid Metachromasy
Acrolein-fixed, polyester wax-embedded tissue sections showed excellent preservation of light microscopic architecture and, when stained with toluidine blue, intense color contrast between DNA, which stained orthochromatically, and RNA, which stained metachromatically. This method has practical value for differentiating DNA from RNA in the same section. The color contrast was impaired by substi...
متن کاملLocked nucleic acids: promising nucleic acid analogs for therapeutic applications.
Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides f...
متن کاملUse of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions
Unnatural nucleosides have been explored to expand the properties and the applications of oligonucleotides. This paper briefly summarizes nucleic acid analogs in which the base is modified or replaced by an unnatural stacking group for the study of nucleic acid interactions. We also describe the nucleoside analogs of a base pair-mimic structure that we have examined. Although the base pair-mimi...
متن کاملNMR studies on protein-nucleic acid interaction.
A special section of this issue is devoted to the study of protein-nucleic acid interaction by NMR. This topic constitutes a fruitful area of research already for several decades. Interactions between proteins and nucleic acids are involved in many essential cellular processes such as replication, transcription, translation, DNA repair, and the regulation thereof. Structural and dynamics studie...
متن کاملOn Thymus Nucleic Acid
A consideration of the earlier investigations of the nucleic acids would lead us to the conclusion that these substances yield among their hydrolytic products four purin derivatives, namely, xanthin, hypoxanthin, guanin, and adenin. Of these four bases hypoxanthin was the first discovered in this connection and was for a long time looked upon as the most constant in its occurrence, and, therefo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the agricultural chemical society of Japan
سال: 1961
ISSN: 0002-1407,1883-6844
DOI: 10.1271/nogeikagaku1924.35.3_280